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Migraine Family Study

The study sample consists of migraine patients visiting headache clinics, from which extensive questionnaire data for headache and co-morbid disorders has been collected. The study combines the best possible phenotyping in large samples with cutting edge genetic techniques, including high throughput genotyping and novel tools of statistical genetics. The aim is to identify gene variants and assess their impact in ascertained family and case control samples and subsequently study their population relevance in large international population samples.

University of Helsinki

Principal Investigators and contact persons:
Mikko Kallela, firstname.lastname (at)
Aarno Palotie, ap8 (at)

Key reference:

Genome-wide association study of migraine implicates a common susceptibility variant on 8q22.1. Anttila V, Stefansson H, Kallela M, Todt U, Terwindt GM, Calafato MS, Nyholt DR, Dimas AS, Freilinger T, Müller-Myhsok B, Artto V, Inouye M, Alakurtti K, Kaunisto MA, Hämäläinen E, de Vries B, Stam AH, Weller CM, Heinze A, Heinze-Kuhn K, Goebel I, Borck G, Göbel H, Steinberg S, Wolf C, Björnsson A, Gudmundsson G, Kirchmann M, Hauge A, Werge T, Schoenen J, Eriksson JG, Hagen K, Stovner L, Wichmann HE, Meitinger T, Alexander M, Moebus S, Schreiber S, Aulchenko YS, Breteler MM, Uitterlinden AG, Hofman A, van Duijn CM, Tikka-Kleemola P, Vepsäläinen S, Lucae S, Tozzi F, Muglia P, Barrett J, Kaprio J, Färkkilä M, Peltonen L, Stefansson K, Zwart JA, Ferrari MD, Olesen J, Daly M, Wessman M, van den Maagdenberg AM, Dichgans M, Kubisch C, Dermitzakis ET, Frants RR, Palotie A; International Headache Genetics Consortium. Nat Genet. 2010 Oct;42(10):869-73