Cohort |
PI |
URL |
ATBC study |
Jarmo Virtamo / KTL |
www.ktl.fi/portal/suomi/osastot/epidemiologia_ja_terveyden_edistaminen/yksikot/syovanehkaisytutkimusyksikko /syovanehkaisytutkimus_(setti)/ |
Finnish Twin Cohort |
Jaakko Kaprio KTL and HU |
www.twinstudy.helsinki.fi |
Finrisk |
Erkki Vartiainen / KTL |
http://www.ktl.fi/portal/english/osiot/research,_people___programs/epidemiology_and_health_promotion/units/ chronic_disease_epidemiology_unit/the_national_finrisk_study/ |
Pekka Karhunen / TaY |
www.uta.fi/laitokset/laaket/bio/research/forensicmedicine.html |
|
Health 2000 |
Arpo Aromaa / KTL |
http://www.ktl.fi/terveys2000/ |
KTL Psychatric collections |
Jouko Lönnqvist / KTL |
http://www.ktl.fi/portal/suomi/osastot/mielenterveys_ja_alkoholitutkimus/tutkimus/mielenterveys/epidemiologia_ja_genetiikka/ |
Northern Finland Birth Cohort |
Marjo-Riitta Järvelin / OU |
http://cc.oulu.fi/~kttylwww/psko1966.html |
KTL: National Public Health Institute, Finland; HU: University of Helsinki; Tay: University of Tampere; OU: University of Oulu
Sample collections of the cohorts
Cohort |
Total cohort (n) |
DNA samples (n)(%) |
Average DNA yield** |
Serum (n) |
Other samples*** |
|
ATBC study |
29 000 |
2122 (7.3)* |
144 |
29 000 |
n |
|
Finnish Twin Cohort |
42 000 |
12040 (28.7) |
324 |
1 000 |
sess |
|
Finrisk 1992-2002 |
23 297 |
20850 (89.5%) |
278 |
From all |
sess |
|
92 |
6051 |
5784 |
154 |
6025 |
sess |
|
97 |
8447 |
8791 |
285 |
7150? |
sess |
|
02 |
8799 |
8758 |
- |
8788 |
sess |
|
Helsinki Sudden Death Study |
1400 |
1400 (100) |
- |
700 |
ft, pt(ss), u(ss) |
|
Health 2000 |
7419 (8000) |
6824 (91.9) |
401 |
8000 |
sess |
|
KTL Psychatric collections |
9728 |
2142 (22.0) |
240 |
- |
c(ss) |
|
Northern Finland Birth Cohort 1966 & 1985-86 |
~12 000 |
11652 |
300 |
From all |
p, sess |
|
Helsinki Sudden Death Study |
700 |
0 |
0 |
0 |
pt, c(ss), ft(ss) |
|
Autoklinikat |
57 000 |
0 |
0 |
57 000 |
p |
|
Mini-Suomi |
7217 |
0 |
0 |
7217 |
p, u |
|
Total 212 358 excluding pathological collections
ss=subsample
sess =several subsamples
*extraction unfinished, samples from all
**amount still left
*** Plasma= p; frozen tissue = ft; tissue in paraffin =pt; urine= u; cells= c; nail clippings =n;
Phenotype and registry data.
Cohort |
Average follow-up yrs* |
Clinical examination at baseline |
Questionnaire topics† |
Interview topics |
Laboratory examinations |
Key publication describing study setting |
ATBC study |
12 (re+rg)** |
doctor |
Cardiovascular risk factors |
Life style, risk factors |
All: Cholesterol, HDL, α-tokopherol, β-carotene, pepsinogen-1 |
Marantz et al. 1994 |
Finnish Twin Cohort |
20-28 (re+rg) |
nurse/doctor (ss) |
Disease-oriented |
Disease-+several life style related |
Several but only in subsamples: GWA (n=152), lipids, inflammation, genotyping (genome-wide scan from app. 1000 individuals) |
Kaprio et al. 2002 (a+b) |
Finrisk |
30-2 yr (rg) |
nurse |
Life style, risk factors |
Life style, risk factors |
All: cholesterol, HDL, triglyserides (4hr fasting sample). Subsamples (GWA (n=2500), inflammation, thrombosis, OGT) |
Vartiainen E et al 2002 + web |
Forensic collections |
no |
autopsy |
- |
Life style, (subset) †† |
Candidate genes in HSDS |
Ilveskoski et al 1999 |
Health 2000 |
2 (rg) |
Doctor, dentist |
Health related |
Health related |
GWA (n=2200), ApoE2/3/4 genotypes, candidate gene analyses, lipids, uric acid, insulin, glucose (ss) |
Web (Table Y) |
KTL Psychatric collections |
10 (rg) |
Doctor+nurse |
Addictions, somatic diseases |
Psychiatric interview (n=1200) |
GSD, some candidate genes, app. 1000 individuals |
Hovatta 1998 |
Northern Finland Birth Cohorts |
36+16(re+rg) |
nurse |
Disease-oriented |
|
GWA (n=4988), insulin, Hb, glucose, hs_CRP, IgG, IgA, candidate gene genotyping (ss) |
Heikura et al 2003 |
Helsinki Sudden Death Study |
no |
Autopsy/histological diagnosis |
n/a |
n/a |
Histological diagnosis, clinical data |
- |
Autoklinikka |
36-30 (rg) |
Nurse, doctor ss |
Life style, risk factors |
Life style, risk factors |
Hb, Hkr, EKG (ss) |
Aromaa1981 |
Mini-Suomi |
22 (rg) |
Doctor, dentist |
Life style, risk factors |
Life style, risk factors |
EKG, spirometry, Hkr, cholesterol, HDL, triglyserides, GGT, fs-glucose, kreatinine, sess (lipidfractions, Na, K…) |
Aromaa et al 1989 |
* All cohorts with registry follow-up data use death registry and hospital discharge registry as their primary source of follow-up data
** rg=registry follow-up; re=re-call of the participants
† all listed questionnaire studies record basic clinical characteristics, such as height and weight
†† interview of a living associate (relative) for a subsample
HSDS=Helsinki Sudden Death Study
GSD=Genome-wide scan data (microsatellites)
GWA=Genome-wide association data
Ss= subsample
sess =several subsamples
References
Aromaa A. Kohonnut verenpaine ja sen kansanterveydellinen merkitys Suomessa. (English summary) KELA AL: 17. Helsinki 1981
Aromaa A, Heliövaara M, Impivaara O, Knekt P, Maatela J, Joukamaa M, Klaukka T, Lehtinen V, Melkas T, Mälkiä E, Nyman K, Paunio I, Reunanen A, Sievers K, Kalimo E, Kallio V. Terveys, tomintakyky ja hoidontarve Suomessa. Mini-Suomi terveystutkimuksen perustulokset. (English summary) KELA AL: 32. Helsinki and Turku 1989.
Heikura U, Taanila A, Olsen P, Hartikainen AL, von Wendt L, Jarvelin MR. Temporal changes in incidence and prevalence of intellectual disability between two birth cohorts in Northern Finland. Am J Ment Retard. 2003 Jan;108(1):19-31.
Hovatta I. "Molecular genetics of familial schizophrenia and PLO-SL". PhD. Thesis University of Helsinki, 1998.
Ilveskoski E, Perola M, Lehtimaki T, Laippala P, Savolainen V, Pajarinen J, Penttila A, Lalu KH, Mannikko A, Liesto KK, Koivula T, Karhunen PJ. Age-dependent association of apolipoprotein E genotype with coronary and aortic atherosclerosis in middle-aged men: an autopsy study.Circulation. 1999 Aug 10;100(6):608-13.
Kaprio J, Pulkkinen L, Rose RJ. Genetic and environmental factors in health-related behaviors: studies on Finnish twins and twin families.
Twin Res. 2002 Oct;5(5):366-71. (a)
Kaprio J, Koskenvuo M. Genetic and environmental factors in complex diseases: the older Finnish Twin Cohort.
Twin Res. 2002 Oct;5(5):358-65. (b)
The ATBC Cancer Prevention Study
Group. The Alpha-Tocopherol, Beta-Carotene Lung Cancer Prevention Study:
design, methods, participant characteristics, and compliance. Ann
Epidemiol 1994;4:1-10.
Vartiainen E, Laatikainen T, Tapanainen H, Salomaa V, Jousilahti P, Sundvall J, Salminen I, Männistö S, Valsta L. Suomalaisten sydän- ja verisuonitautien riskitekijät FINRISKI-tutkimuksessa 1982-2002. Suom Lääkäril 2003;41:4099-4106.
